Gainsborough is a village in the Rural Municipality of Argyle No. 1, located in the southeastern corner of Saskatchewan. The community sits on Highway 18, approximately 6 kilometres from the Manitoba border and 19 kilometres from the North Dakota border to the south. It is a farming community within Census Division No. 1.
The first post office was established on April 1, 1884, when the community was known as Antler. On September 1, 1885, the name changed to Gainsborough, after Gainsborough, Lincolnshire in England, which was the former home of J. J. Sadler, an early settler in the area.